does blood type affect covid vaccine side effects does blood type affect covid vaccine side effects

In a study published back in March 2020, researchers in China found that blood group A was associated with a higher risk for acquiring COVID-19 compared with non-A blood groups, whereas blood group O was associated with a lower risk for the infection compared with non-O blood groups.2 This may be what prompted a slew of similar studies in other countries as COVID-19 spread. Water (H2O) serves as a positive control. "I expect the COVID-19 booster shot to become an annual recommendation with small changes needed each year to keep up with, and protect against, new variants that arise," she explains. Not necessarily. Studies of the accuracy of serologic tests for anti-SARS-CoV-2 immunoglobulins may assess whether there is variation in antibody titers by ABO and Rh status, the authors noted. The most common symptoms of long COVID are: extreme tiredness (fatigue) shortness of breath. Side-effects such as fever, chills, tiredness and headache throughout the body were more common after the second dose of the vaccine, the US Centers for Disease Control said. These studies are fascinating from a scientific perspective, but at this point, they have no practical implications for the way we live our lives and the precautions we should be taking to protect others and ourselves. Specifically, they sought out folks in the U.S. diagnosed and hospitalized with COVID-19. I have read that it is important that a large percentage of people get the vaccine. A Vancouver study revealed people with blood types A, B or AB had worse outcomes than others. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. According the ZOE Covid symptom study released last month and looking only at the Pfizer jab, about a third of vaccine recipients who had previously had Covid reported having a whole-body side-effect (such as chills), compared with 19% of those who had not had Covid. Erythrocyte lysis with addition of the SARS-CoV-2 spike protein S1. Diet is also key, and as you are probably well aware of by now if youve been following me a healthy microbiome is a must. Sat, Sun 10 a.m. 4 p.m. She presented to a local hospital, where she was noted to have a 3 g/dL hemoglobin decrease and received 2 units of packed red blood cells. The mean age was 53.8 years and 29% were men. This study reported descriptive epidemiology for many potential AESIs for safety follow-up of COVID-19 vaccines from a random Swedish population. Hearst Magazine Media, Inc. All Rights Reserved. For all four vaccines, pain at the injection site. Similar figures were true for Moderna recipients, as 59% of patients indicated they'd experienced fatigue after their shot, but only 4% reported it at a severe level. Another recently published study, this time co-authored by Canadian Blood Services chief scientist, Dr. Dana Devine, revealed that people with blood groups A or AB were more likely to have a severe case of COVID-19 compared to those with O or B type blood.4. "The data that was already generated from the bivalent BA.1 vaccine, the human data, really gave the FDA the confidence that they could approach approving this new bivalent shot," Dr. Martinello says, adding that this kind of approval system is similar to the annual flu vaccine. According to Public Health England, most side-effects from two Covid vaccines Pfizer/BioNTech and Oxford/AstraZeneca are mild and short-lived. The relative protective effects of O, Rh-, and O- blood groups were greatest in patients younger than age 70. In short, it might feel like you have the flu. 244 Wood Street Similarly, type B individuals only have anti-A antibodies. By signing up, you are consenting to receive electronic messages from Nebraska Medicine. What do I need to know about the AstraZeneca vaccine? Pain can be managed with acetaminophen, like Tylenol, or ibuprofen, Litwack said. In April, researchers at Columbia University reported similar risks associated with Type A blood after blood-typing more than 1,500 New Yorkers and testing them for COVID-19. 16 Furthermore, 3 instances of While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. Early reports that some people had severe allergic reactions, particularly to the Pfizer jab, led the UKs Medicines and Healthcare products Regulatory Agency (MHRA) to offer new recommendations, including that anyone receiving the Pfizer jab be monitored for 15 minutes after the event. While this doesnt mean a free pass for anyone with a less susceptible blood type, it might help begin to solve some mysteries over why the coronavirus has more devastating effects on some individuals but not others. It is not clear to me why. "This is a similar process that we go through with our annual influenza vaccination.". Differences in how people have reacted to COVID-19and whyhave occupied researchers throughout the pandemic. COVID-19 vaccine side effects can vary depending on a person's age, sex, or health. headache, muscle pain, joint pain. Cambridge, MA 02142, MIT Lincoln Laboratory A 2012 meta-analysis found that having a non-O blood type was among the most important genetic risk factors for venous thromboembolism.5. Health Canada and PHAC are aware of an updated report released on Monday February 6, 2023 by the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA) on findings from the Vaccine Safety Datalink. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. The Covid-19 vaccine side effects that specifically affect women . The information in this story is accurate as of press time. Side. Can COVID-19 Cause Diabetes? COVID-19 vaccine side effects Mild vaccine side effects are usually not a cause for concern, as the symptoms likely indicate the body is building protection against COVID-19. Copyright 2023 by American Society of Hematology, Aplastic anemia, transfusion dependence, microvascular small bowel thrombosis, renal failure, smooth muscle dystonia, Transfusion dependence, hemoglobinuria, smooth muscle dystonia, Hemoglobinuria, fatigue, extravascular hemolysis with transfusion dependence on C5 inhibition, Last dose ravulizumab prior to vaccination, Fever, myalgia, headache, fatigue, hemoglobinuria, Fever, fatigue, dark urine, vomiting, diarrhea. You could . Secondary outcome results indicated that type O blood group had an aRR of 0.87 (95% CI, 0.78-0.97) for severe COVID-19 illness and death versus all other blood groups and Rh- status had an aRR of 0.82 (95% CI, 0.68-0.96) compared to . They include: tenderness, swelling, and. You might run a fever and experience body aches, headaches and tiredness for a day or two. For the most up-to-date information on COVID-19, please visit online resources provided by the CDC, WHO, and your local public health department. Patients 2, 3, and 4 experienced severe hemolysis with 2 to 4 g/dL hemoglobin decrease. But an even better way to get your blood type tested is to donate blood, which, by the way, is still a safe thing to do, even during a pandemic. This seems to be an issue with DNA adenovirus vector vaccines the biology of which is yet to be fully understood, said Prof Saad Shakir, director of the independent Drug Safety Research Unit. Sleep expert Dr. Michael Breus strongly advises that getting a good nights sleep is essential before you go in for the vaccine in order to build a healthy antibody response.7. One of these areas contains genes that determine blood type along with other genes that are known to be associated with immune function. Is this true? At this point in time, there does not appear to be any relationship between blood type and COVID-19related severity of illness or mortality.". She missed 2 doses of danicopan immediately after her second vaccination due to concerns that the drug may interfere with vaccine potency; therefore, danicopan was not at therapeutic levels at the time of her reaction. designed and performed research; J.Y., B.A.Y.C., E.M.B., and S.C. interpreted results and edited the paper; R.A.B. When side effects occur, they typically last just a few days. As a result, our understanding of the connection to blood type continues to evolve. - Drug Monographs "People with type O blood may be more susceptible to norovirus," said infectious disease expert Amesh A. Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security. Information on this website is provided for informational purposes only and is a result of years of practice and experience by the author. Researchers found no link between blood type and COVID-19 risk, adding that more research was needed on the topic. You sit 7 feet away from both of them. Side effects may even feel like flu and might affect your ability to do daily. Patient 3 is a 32-year-old woman with a 10-year history of PNH on ravulizumab with her last dose 4 weeks prior to vaccination. Investigators also suggested further research on how ABO status may moderate venous thromboembolism occurrence, a known complication of COVID-19, since blood group O patients have been associated with a decreased risk of venous thromboembolism in prior research. denotes no information is available; AST, aspartate amino transferase; LDH, lactate dehydrogenase; N/A, not applicable; RBC red blood cell. Your comment will be reviewed and published at the journal's discretion. For the primary outcome, analyses were further stratified by patients aged younger than 70 years vs 70 years or older. Patients with type O and rhesus negative (Rh-) blood groups may have a lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019 (COVID-19) illness, according to a study published in the Annals of Internal Medicine. The first is called the innate response and includes that chemical fire alarm. Visit the MHRA Yellow Card report for the latest data on the reported side effects of Covid-19 vaccines. - Full-Length Features COVID vaccines may have some side effects. And would my blood type be part of my record at MIT Medical maybefrom lab work Ive had done in the past? Quite a bit of research has been published on the topic of blood type and its role in determining COVID-19 risk. Download Some of the potential side effects of a vaccine - fever, chills, headache and fatigue - can seem very similar to the symptoms of the illness it's meant to prevent. The most common side effects of COVID-19 vaccination are not specific to diabetes. Both of these studies were posted to the MedRxiv website, where researchers share preliminary, unpublished data, before it has undergone peer review. NIH 'Very Concerned' About Serious Side Effect in Coronavirus Vaccine Trial. Recent data suggest the SARS-CoV-2 spike protein binds heparan sulfate on nucleated cells9 and amplifies the alternative pathway of complement through interference with the binding of CFH, an alternative pathway inhibitor.5 However, CFH primarily binds sialic acid on human erythrocytes,10 and mature erythrocytes express little heparan sulfate.11. Adverse reactions appear time-limited and can be managed with supportive care and transfusions as needed. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.14 Recently, we demonstrated that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein leads to amplification of the alternative pathway of complement on cell surfaces through competition with complement factor H (CFH) for binding heparan sulfate.5 Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells. Researchers have been talking about blood type and COVID-19 susceptibility for months. Our clinicians do not order blood typing routinely, other than for pregnant patients. However, experts say it is too soon to be sure the J&J jab is causing the blood-clotting problem, and even if it is, the risk is very low. Read said: Usually if you have experienced a natural infection in this case with the coronavirus and are then challenged with something that looks quite similar in this case the vaccine an efficient immune system responds very quickly to the second challenge.. A transcript of the podcast is below the summary. Chills. Fever. Deep, healing sleep, reducing stress, walking or other forms of gentle exercise, plus pampering yourself, are important for helping to create a robust immune system. Laboratory tests 1 week later, as symptoms were resolving, showed >4 g/dL hemoglobin decrease from his baseline. The analysis turned up gene variants in two regions of the human genome that were associated with severe illness and greater risk of COVID-19-related death. Got a question about COVID-19? But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a persons blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. Should you eat before? Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, shopping, and lifestyle trends, with work appearing in Womens Health, Self, Prevention, Forbes, Daily Beast, and more. Instead, it seems that a specific variant in the ABO gene is associated with lower risk. Hoarseness: How Likely Is It to Be a COVID Symptom? "Masks are important because they filter out some of the virus and decreases the viral load, which makes the infection less severe," says Dr. Anderson. Earlier this month the MHRA said that while not yet proved, there was growing evidence to suggest this syndrome could be caused by the AstraZeneca jab, while the European Medicines Agency said there was a possible link and noted the syndrome should be listed as a very rare side-effect of the vaccine. This difference in risk of testing positive for COVID-19 seemed to hold even when researchers took into account age, sex, body mass index, ethnicity, and co-morbidities (i.e., pre-existing conditions like heart disease and diabetes). Fatigue. It's expected that the likelihood of severe side effects caused by COVID-19 vaccines will decrease as patients receive more boosters over the next few years, Dr. Brown explains. You may have heard that blood type matters when it comes to contracting COVID-19. As a whole, experts recommend that peopleregardless of blood typekeep following CDC guidelines to prevent the spread of COVID-19. We have seen that older people are getting much milder side-effects. "The side effects that we see occur early on and that's it," Goepfert said. Characteristics of patients with PNH and COVID-19 vaccine reactions. Researchers have been talking about blood type and COVID-19 susceptibility for months. Individuals with Type A blood type also represented a higher percentage of patients who succumbed to the illness 41 percent versus 25 percent for Type O. Dr. Gundry and her team continue to investigate how heart injuries caused by COVID-19 developand the impact of red blood cells on the infection. Now, a "Covid arm" is different from a skin reaction that . These cases have been mild and self-resolving. Health's content is for informational and educational purposes only. Ray JG, Schull MJ, Vermuelen MJ, Park A. The reason behind this association remains unclear. A comprehensive review of studies published in Seminars in Vascular Surgery in September 2021 examined peer-reviewed journal articles published from March 2020 to January 2021. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a person's blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. Blood types are split up into four major groups, all dependent on the presence or absence of two specific antigens on the surface of the blood: A and B, according to the American Red Cross. Current authorizations are based on these previous studies, as laid out by health regulators at the Centers for Disease Control and Prevention (CDC). While it's not a hard-and-fast rule, CDC officers have made recommendations to Americans to consider delaying receiving this bivalent booster vaccine at least three months from the date of your last COVID-19 infection. There was also a moderately increased risk of infection in people with Rh-positive blood type. The first study, conducted by Danish researchers, analyzed data from more than 473,000 people tested for COVID-19 with data from a control group of more than 2.2m non-tested people. Thank you for submitting a comment on this article. Read More Safety of COVID-19 Vaccines Some people have no side effects. Hear the whys of three Black colleagues from Nebraska Medicine. However, while the AstraZeneca jab uses a chimpanzee cold virus, the J&J jab uses a human cold virus to do so. Patient 1 had a presumptive thrombotic manifestation. There have been multiple studies on blood types and COVID-19 risk. S1 did not increase hemolysis of PNH erythrocytes as compared with aNHS alone (Figure 1). Building E23 Your use of this website constitutes acceptance of Haymarket Medias Privacy Policy and Terms & Conditions. Annex V Earlier studies have also found that blood type is correlated with the risk of testing positive for SARS-CoV2. However, a genome-wide association study (GWAS) recently published in the New England Journal of Medicine (NEJM) is both consistent with, and potentially explains, these earlier results. - Conference Coverage The Food and Drug Administration sees a possible risk of Guillain-Barre syndrome with Pfizer 's RSV vaccine for older adults and has asked the company to conduct a safety study if the shot is . You also shouldn't expect a lighter immune response, either. Common (not rare) side effects of COVID-19 vaccine. Patients 5 and 6 received both doses of the Pfizer-BioNTech BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine without clinical or laboratory signs of hemolysis. Blood type has been identified as a risk factor in many diseases, from cancer to venous and arterial thromboembolism. The other half is the adaptive response which learns and then remembers how to fight an infection by designing B . All vaccines could cause some degree of reaction, and the same is true for COVID-19 vaccines. associate medical director of infection prevention at UCI Health and a professor at the University of California, Irvine, posits an analogy that this bivalent vaccine is like a riff on a standard brownie recipe: "You're going to have almost the same ingredients, and bake it for the same time at the same temperature but this time, instead of just chocolate chips, you add dark chocolate, too," she tells Good Housekeeping. Your friend sits next to the person infected. What should you have on hand at home? Gloria F. Gerber, Xuan Yuan, Jia Yu, Benjamin A. Y. Cher, Evan M. Braunstein, Shruti Chaturvedi, Robert A. Brodsky; COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria. We hope youre enjoying the latest clinical news, full-length features, case studies, and more. Headaches. However, they did not find strong evidence for a relationship between blood group and risk of intubation or death. muscle pain . People may. For some people, the second [] They noted that this area also includes a genetic variant associated with increased levels of interleukin-6, which plays a role in inflammation and may have implications for COVID-19 as well. pain upon and after vaccination for 60% of participants. performed research, collected and analyzed data, and wrote the first draft of the manuscript; X.Y. The O- blood group also seemed protective, with an aRR of 0.74 (95% CI, 0.66-0.83) and an ARD of -8.2 per 1,000 (95% CI, -10.8 to -5.3). The latest Omicron COVID-19 vaccine may lead to similar side effects caused by earlier versions, which include injection site pain, fatigue, fever and more. The lymph nodes become tender and swell up within two to four days after the COVID-19 vaccination, and the swelling can last up to six to eight weeks. 4 natural ways to turn back time, 2 foods you should never eat if you have a virus, About Donna Gates Nutrition & Gut Health Expert, Kimchi the probiotic superstar thats a must for allergies. This study provides insight into the mechanism of pharmacodynamic breakthrough precipitated by COVID-19 vaccination in patients with PNH on ravulizumab. However, for the Pfizer jab the reverse appears to be true. Following incubation at 37C for 1 hour, absorbance at 405 nm was measured in the cell-free supernatants. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. One study published in the Journal of the American Medical Association (JAMA) in April of 2021, reviewed nearly 108,000 COVID-19 cases. Some less common side effects include nausea and swollen lymph nodes (especially in the armpit). This is called a breakthrough infection. The risk for individuals for Type O blood appeared to be significantly lower, just 26 percent of the cases versus 34 percent of the healthy control group. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Muscle aches. Contribution: G.F.G. The reduction in risk appeared to be about 9 to 18 percent for people with an O blood type compared with other blood types, among which there was little difference in susceptibility. None of these patients were previously transfused in the past year. Using this data, 23andMe launched their COVID-19 Severity Calculator last year. But how? But no vaccine is 100% effective, so some people who are fully vaccinated might still become infected with COVID-19 and get sick. You'll notice that all of these side effects warnings are the same that came with original vaccine formulations. "We do not expect [the public] to experience anything that would be out of the ordinary from our experience with the original vaccination.".