Safety Data Sheet for Cellulose microcrystalline 102331. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. 3 0 obj
Millipore. It works as a moisture sponge and permits the controlled growth of spheroids. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Magazine: Material safety data sheet - FMC Corporation. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Go to Investor Relations. l~5C
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Validity Area. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Meet our leadership team. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . If you are already a ChemPoint customer then sign up for access to our online ordering website. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. endobj
MCC helps in the formation of spheres because of its . <<
Product and Company Identification . B;vLZpHU%ChUyD+[ Microcrystalline Cellulose Side Effects. . Learn about FMC's industry leading goal of net-zero emissions by 2035. PDF (28.38 mb) 2022 Corporate Fact Sheet. endobj
Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm . 1.3. ( : 1. Cellulose microcrystalline. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. It is a white, free-flowing powder. cas:9000-11-7 msds Carboxymethyl cellulose. Date Approved: 05/25/2010. %
on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. 102331. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. 6 /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. MSDS Ref. Thus, Avicel contributes no or very few calories to the food system. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. By producing Avicel . You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. <>
With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. endstream
LOT #: Available upon request. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). /Parent 3 0 R
Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. }o]X4]. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Find answers in our support articles. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. [FMC Study Number I92-1464]. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Alginates also function as actives in some anti-reflux products. In large quantities it provides dietary bulk and may lead to a laxative effect. 1 0 obj
Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. gac74
[#B6`Wnw7 By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. X]s
;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. SCMm_>x^O9l (n. endobj
HMo@9, U Q!R/1*;` It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. . : 160182 Date Approved: 05/25/2010 Revision No. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
Cu:3(]N"AQdUt~h|P Van Veen, G.K. Bolhuis, Y.S. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[
EMCOCEL 90 M. 130. Instead, they obtained a stable colloidal suspension. Truly distinctive drug delivery solutions. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. q86@on$^X_HuH;3` Avicel PC 611 (FMC Biopolymer) Supplied by. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. EMCOCEL XLM 90. However, consumption of large quantities of the material may have a laxative effect. High performance lubricant that brings more to the tablet. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
CAS #: 9004-34-6 . The short-term limit for total inhalable dust is 20 mg/m3. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@
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Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Cellulose microcrystalline for column chromatography. Product Name: Microcrystalline Cellulose 1.2. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. AVICEL RC 581. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Page 1 of 8. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Watch Now. <> bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O cas:9032-51-3 msds CELLULOSE PAB. 8 0 obj MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. %
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If breathing is difficult or if . SUBSTANCE IDENTIFICATION 1.1. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4(
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: 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . };khd5x=fr No. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; PDF (4.11 mb) Footer menu 1. stream Learn about FMC's differentiated biologically-based crop solutions. Regulatory Information Chemical Formula: (C6H10O5)n 1.4. We can send by Fedex, by ship or by plane according to international rules. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Material safety data sheet - FMC Corporation. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. zW0}
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3Fz. Microcrystalline Cellulose / Avicel PH-102. X\o^ It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. CAS No. Aqueous suspensions of microcrystalline cellulose have . This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Revision No. . No. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. %PDF-1.4
This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. 5 0 obj
Trademarks: Avicel PH-102. : 9004-34-6 Date Approved: 01/31/2008 . Revision No. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. G2W4de=u183KGH{ vQ#4:1\wc These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. >>
Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Molecular weight: Not Applicable 1.5. . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. This Microcrystalline Cellulose . q9;v80 In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Buy Chemicals. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. The cellulose molecule is formed through repeated condensation of cellobiose units. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. CAS #: 9004-34-6 More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. ( The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. PharmaCentral 2021 . Battista, O. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Performing this action will revert the following features to their default settings: Hooray! To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Created Date: 2/10/2020 8:51:41 PM . ChemicalBook. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. /Contents 4 0 R
Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . ). CAS #: 9004-34-6 1.6. It is . Avicel PH-200 microcrystalline cellulose NF, Ph. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Are you looking for information about products and services by region? ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. : 160182. "l%I-*j|-)@
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As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Microcrystalline Cellulose / Avicel PH-102. /Resources 2 0 R
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FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. P}MFbN#[>r(y Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers.
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