fibroscan score fatty liver cap fibroscan score fatty liver cap

The nurse said we don't have the cap score. 2014;29(7):1470-6. doi: 10.1111/jgh.12557. Mertens, J. et al. Shear wave speed and stiffness, and CAP* may be used as an aid in the clinical management of pediatric patients with liver disease. J. Appl. Non-alcoholic fatty liver disease and the interface between primary and secondary care. CAS A p-value<0.05 was considered statistically significant. Careers. J. Appl. Published by Elsevier Ltd.. All rights reserved. 10 0 obj If patients remain undiagnosed and untreated, they may go on to develop irreversible cirrhosis of the liver. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. BMC Gastroenterol. Finally, FAST score performed least well in terms of calibration in low prevalence populations, and caution should be exercised when interpreting the score in these settings, although discrimination performance of the score was good. Diabetes Metab. World J. Gastroenterol. Many people with liver disease(s) have a result that is higher than the normal range. 82(4), 801805 (2005). Basal metabolic rate in morbidly obese patients with non-alcoholic fatty liver disease. This site needs JavaScript to work properly. 13(1), 112 (2021). PMC Variables with a p-value<0.2 in univariate analysis were enteredinto the multivariate model using the backward selection approach. 7(3), 476487 (2016). Obes. >> Clipboard, Search History, and several other advanced features are temporarily unavailable. Ther Adv Endocrinol Metab. Diabetes Care 27(10), 24162421 (2004). Critical revision, R.J. Acquisition of data, S.M.S.J. Mechanisms of altered protein turnover in chronic diseases: A review of human kinetic studies. Insulin resistance was estimated using the following formula: HOMA-IR=[Fasting insulin (U/mL)fasting glucose (mmol/L)/22.5]. Diagnostics (Basel). Unauthorized use of these marks is strictly prohibited. The table below shows liver diseases, ranges of fibrosis results, and the matching fibrosis score. Your doctor may also order other tests to evaluate your liver, such as blood tests, other imaging scans, or biopsies. For instance, Tarantino et al., showed that morbidly obese NAFLD patients with metabolic syndrome had higher BMR in comparison to NAFLD individuals with a similar weight but without metabolic syndrome17. /F9 9 0 R doi: 10.5005/jp-journals-10018-1364. Google Scholar. Physiol. Hypertens. Deurenberg, P. Limitations of the bioelectrical impedance method for the assessment of body fat in severe obesity. Diabetes Care 27(6), 14051411 (2004). Gougeon, R. et al. J. Med. Intensity of resistance exercise determines adipokine and resting energy expenditure responses in overweight elderly individuals. Gastroenterol. << Nutrients 11(8), 1830 (2019). All authors have read the manuscript and approved the manuscript. Considering the progressive prevalence and co-occurrence of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), as well as the current evidence suggesting the elevated levels of basal metabolic rate (BMR) among these individuals, the present study aimed to identify factors determining hypermetabolism in such subjects. Keep up with the latest developments in gastroenterology as well as news about our practice and the events we sponsor. Physiol. Please enable it to take advantage of the complete set of features! ADS 2017;15:1120. The fibrosis result is measured in kilopascals (kPa) It is normally between 2 and 6 kPa. >> There is a positive association between diabetes and REE15,37. Hypermetabolism was defined as an elevated measured REE>110% of the predicted REE. Med. The first score measures liver stiffness and the second score measures liver fat. A high performance liquid chromatography analyzer (Tosoh, Japan) was used to measure the levels of HbA1c. x}%q>00 h!h!,B.sGydUHHnno7/??kv=?mT//zI~n?nCOO5g=~|?|onnso1 O6VW/w0vc]!? Publication Paul et al. Nutrients 13(12), 4522 (2021). Correction to Lancet Gastroenterol Hepatol 2020; 5: 36273, Statement on offensive historical content, Time between FibroScan and liver biopsy, median (IQR); range, Time between FibroScan and blood analyses, median (IQR); range, Time between liver biopsy and blood analyses, median (IQR); range, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. Scarring of the liver is measured by four stages. Protein turnover is assumed to account for 20% of REE in healthy subjects41, and elevated protein turnover is associated with increased REE42,43 and loss of FFM43. JFC reports speaker fees/advisory board fees from EchoSens during the conduct of the study; and personal fees from NovoNordisk, Intercept, and Alnylam, outside the submitted work. The categorical variables were reported as number (%). There are several weaknesses to this study, including the requirement for a FibroScan device, which could affect uptake. /Creator ( w k h t m l t o p d f 0 . We use cookies to help provide and enhance our service and tailor content and ads. CAP provides a convenient and patient-friendly method to assess lipid turnover during lifestyle and dietary interventions to combat NAFLD. Both LSM by VCTEand CAP are measured simultaneously without lengthening the examination time. Estimation of resting energy expenditure considering effects of race and diabetes status. Google Scholar. You can keep reading to learn more about your results. A FibroScan is a non-invasive diagnostic tool used to assess the health of your liver. Diabetes Res. Triangles represent deciles of participants grouped by similar predicted risk. A. 2023 Jan 24;23(1):52. doi: 10.1186/s12879-023-08000-w. Macias J, Parra-Membrives P, Sosa-Moreno F, Rincon P, Martinez-Baena D, Fernandez-Fuertes M, Lorente-Herce JM, Martinez RC, Jimenez-Riera G, Corma-Gomez A, Gonzalez-Serna A, Pineda JA, Real LM. The cross-sectional design of the current study made it impossible to draw a conclusion on causality. 678.750000 0] Fibrosis scores allow doctors to plan treatment. 14(2), 8898 (2018). J. Obes. You must have JavaScript enabled to use this form. Would you like email updates of new search results? Liver stiffness measurement (LSM) by vibration-controlled transient elastography and controlled attenuation parameter (CAP) measured by FibroScan device were combined with aspartate aminotransferase (AST), alanine aminotransferase (ALT), or AST:ALT ratio. de Ldinghen V, Vergniol J, Foucher J, Merrouche W, le Bail B. Liver Int. The cells become scarred and cannot divide. You can read the sections below if you would like to learn more. World J. Gastroenterol. Google Scholar. Publication Arslanow et al. Additionally, fibrosis staging may be confirmed . J Hepatol. 1 2 . Your healthcare provider will use your liver stiffness result and medical history to find out your fibrosis score. Independent sample t-test, MannWhitney U test or Chi-square (2) test was used for comparison between groups as appropriate. In patients with NAFLD and T2DM, hypermetabolism has a direct association with adiponectin, physical activity, ALT and diastolic blood pressure, but a diverse relationship with FFM. Miele, L. et al. We found that the higher level of ALT was an independent factor predicting hypermetabolism in T2DM individuals with NAFLD. J. Clin. However, there is inadequate evidence regarding the threshold of blood glucose in which REE is increased38. The LSM and CAP measurements are carried out simultaneously, and the median values of more than ten valid measurements are used to quantify liver . Diabetes Care 40(3), 419430 (2017). Vitaminol. You may have less scarring than your results suggest. Echosens and UK National Institute for Health Research. Diagnostic performance in the derivation cohort of the FAST score for the diagnostic of NASH+NAS4+F2 (A) Receiver operating characteristic curve. If you're a patient at MSK and you need to reach a provider after. In the present study, an inverse association between FFM and hypermetabolism was shown. When determining your actual fibrosis score, in addition to your fibrosis measurement, your provider will take into consideration your health history and the grade of steatosis. Reddavide, R. et al. Google Scholar. Rehabil. doi: 10.1093/crocol/otad004. Sabounchi, N. S., Rahmandad, H. & Ammerman, A. Best-fitting prediction equations for basal metabolic rate: Informing obesity interventions in diverse populations. Ultrasonography and FibroScan were performed twice and once, respectively ( Table 5 ). Shen F, Zheng RD, Mi YQ, Wang XY, Pan Q, Chen GY, Cao HX, Chen ML, Xu L, Chen JN, Cao Y, Zhang RN, Xu LM, Fan JG. Plasma adiponectin levels are not associated with fat oxidation in humans. In a future study, recalibration of scores could be considered to correct miscalibration while keeping the same level of discrimination. Nevertheless, among subjects with concurrent T2DM and NAFLD, our findings suggested that the effect of other factors, including FFM, adiponectin, diastolic blood pressure, physical activity and ALT, on REE was greater than that of glycemia and insulin levels. Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. Nutr. A CAP score that falls anywhere between 238 to 260 dB/m represents 11-33% fatty change in the liver. Epub 2019 Jan 25. Diabetes Care 31(1), 165169 (2008). Clayton-Chubb D, Kemp W, Majeed A, Lubel JS, Hodge A, Roberts SK. | Arq Gastroenterol, 2018. sharing sensitive information, make sure youre on a federal Younossi, Z. M. et al. Rathaus, M. & Bernheim, J. FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A language and environment for statistical computing. An increase in protein turnover has been previously reported in chronic diseases44,45 as well as in diabetes46 and liver disease47. A score below 238 dB/m means the amount of fatty change in your liver is not higher than normal. Epub 2020 Dec 16. Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children. CAP Score Steatosis grade Portion of your liver affected by fatty change 238 to 260 dB/m S1 Less than (11% to 33%) 260 to 290 dB/m S2 Between and (34% to 66%) 290 to 400 dB/m S3 More than (67%) Nutr. Current smoker was attributed to those who had smoked cigarette regularly in the past 6months. This study showed that both NFS and FIB-4 score were similar in patients with fibrosis stages 0 and those with fibrosis stages 1 ( p > 0.05). Nutr. Diagnostic performance in the derivation, Diagnostic performance in the derivation cohort of the FAST score for the diagnostic, Calibration plots in external validation, Calibration plots in external validation cohorts (A) French bariatric cohort (n=110). The CAP score is measured in decibels per meter (dB/m). PNN and JJD were supported by the NIHR Birmingham BRC. Accessibility Res. Another cross sectional study has also reported no relationship between circulating adiponectin and REE in both young and elderly women after adjusting for several confounding factors such as fat mass and FFM53. Nutr. In general, some variables including age, sex, race, weight, height and body composition have been recognized as the most important predictive factors for BMR19. Clin. Before Factors related to hypermetabolism in individuals with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Investig. In addition, there is an intricate and reciprocal association between T2DM and NAFLD3,4,5. Multiparametric US for Identifying Patients with High-Risk NASH: A Derivation and Validation Study. J. Clin. Find the liver disease you have in the first column on the left. Sasso M, Miette V, Sandrin L, Beaugrand M. Clin Res Hepatol Gastroenterol. In spite of the prevalence of T2DM and NAFLD and the importance of estimating appropriate energy expenditure, there is not much literature on exploring factors affecting metabolism in such diseases. Araiza, P. et al. Find your liver stiffness result in the second column from the left. From installation, to training and local support, we provide you with the highest quality of services. -. They may use blood tests or a certain type of MRI to measure scarring and fatty changes in your liver. PubMed Nutrients. 105(2), 141150 (2014). CAP is unique, patented and validated for liver steatosis assessment 2,3: 822 international and peer-reviewed articles support the use of CAP. Results of a FibroScan are available immediately following the scan. Res. CAP provides a convenient and patient-friendly method to assess lipid turnover during lifestyle and dietary interventions to combat NAFLD. FibroScan can be used on patients in need of staging of their NAFLD/NASH, whether their condition is suspected or biopsy-confirmed. The serum levels of insulin, C-peptide and thyroid-stimulating hormone (TSH) were determined by using ELISA kit (Monobind Inc., USA). Article Unauthorized use of these marks is strictly prohibited. Fatty change is when fat builds up in your liver cells. Understanding Your Liver Elastography (FibroScan) Results, All rights owned and reserved by Memorial Sloan Kettering Cancer Center, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Using Your Liver Stiffness Result to Find Your Fibrosis Score, Conditions That Can Affect Your Fibrosis Results, Non-alcoholic Fatty Liver Disease (NAFLD or NASH). Filed Under: FibroScan Tagged With: FibroScan Testing, FibroScan Testing in California, FibroScan Testing near me, gastroenterologist clinic, gastroenterologist clinic in California, gastroenterologist clinic near me, gastroenterologist in California, gastroenterologist near me, inSite Digestive Health Care. Please enable it to take advantage of the complete set of features! Younossi Z, Anstee QM, Marietti M. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Metabolism 121, 154752 (2021). FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study Echosens and UK National Institute for Health Research. Zheng, Y., Ley, S. H. & Hu, F. B. Then, look at the top of that column to see the fibrosis score.[3]. FibroScan is a specialized ultrasound machine for your liver. Your healthcare provider will use your CAP score to find out your steatosis grade. Ali, N. et al. A CAP score that is 290 dB/m or higher represents over 67% fatty change in the liver. Effect of acute resistance exercise on postexercise energy expenditure and resting metabolic rate. When to Use Pearls/Pitfalls Why Use Age years BMI kg/m Impaired fasting glucose/diabetes No 0 Yes +1 AST U/L ALT U/L Platelet count 10/L Albumin g/dL Result: Please fill out required fields. {Wk >=S%ss The levels of FBS, fasting insulin, C-peptide, HOMA-IR, HbA1c, alanine transaminase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, creatinine, TSH, tumor necrosis factor alpha (TNF-), adiponectin and hs-CRP were not significantly different between non-hypermetabolism and hypermetabolism groups (p>0.05). C(aL}%:f~m5"=&@M*M2*38"% Int. The non-invasive CAPis a quantitative surrogate of liver steatosis expressed in decibel per meter (db/m). [2] The table below, adopted from MSK, considers different scores in the context of different liver diseases and can be used to help determine fibrosis score. /Resources 14 0 R Kablawi D, Aljohani F, Palumbo CS, Restellini S, Bitton A, Wild G, Afif W, Lakatos PL, Bessissow T, Sebastiani G. Crohns Colitis 360. Furthermore, our small sample size might have affected the results. /Pattern << FibroScan is an imaging-based diagnostic test developed by Echosens that looks at liver fibrosis (stiffness, scarring) and steatosis (fat) using transient-elastography technology. Med. Can. 12(5), 840845 (2004). /Producer ( Q t 4 . PubMed Central Hepatic steatosis and metabolic risk factors among patients with chronic hepatitis B: The multicentre, prospective CAP-Asia study Yong Wen Leow, Wah Kheong Chan * , George Boon Bee Goh, Vincent Wai Sun Wong, Jian Gao Fan, Young Seok Kim, Seung Up Kim, Atsushi Nakajima, Wai Kay Seto, I. Cheng Lee, Yi Hsiang Huang , Yoon Jun Kim, Jang Jae Young . 2020 Nov;5(11):970-985. doi: 10.1016/S2468-1253(20)30252-1. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. It measures fibrosis (scarring) and steatosis (fatty change) in your liver. (E) French NAFLD cohort (n=182). 2018;3:509517. Zhou, M. et al. This score will range from 100 dB/m to 400 dB/m. /Annots 15 0 R 12, 20420188211055556 (2021). Clin. Federal government websites often end in .gov or .mil. J. Appl. Google Scholar. 3@kJBOxxnV1zC The dotted line represents the calibrations estimated on the data using locally estimated scatterplot smoothing (Loess). The following table shows ranges of CAP scores, and the matching steatosis grades. Rep. 5(6), 513520 (2003). /F8 8 0 R Diabetes Care 31(1), 128133 (2008). Thank you for visiting nature.com. I had a fibroscan done last month with a 17 Kpa (cirrhosis). An official website of the United States government. Please do not use it to ask about your care. << endobj FibroScan elastography of liver tissue can easily detect patients with cirrhosis and fatty liver. For instance, bioelectrical impedance can be affected by some factors including the level of body hydration, body geometry, etc., which could result in the incorrect estimation of body composition78. J Gastroenterol Hepatol. Sayed Mahmoud Sajjadi-Jazi. 8(1), 111 (2011). Your results can range from normal to advanced. To use the table, find the liver disease that you have on the left side of the table. 137(2), 145155 (2008). The authors are thanks to the patients who participated in the study. Med. Here are some helpful terms to know related to your FibroScan results: Fibrosis and steatosis are measured separately from one another. 2019 May;156(6):1717-1730. doi: 10.1053/j.gastro.2019.01.042. CAS HHS Vulnerability Disclosure, Help 12 0 obj s -w64'?*TM|_*>&7VZG|Ze~_-c\;7b 4+T*=P *xtocd~ _t~D8, AuA? 37(2), 558565 (2018). Therefore, the objective of the present study was to find the predictive or determining factors that could affect hypermetabolism in subjects with both T2DM and NAFLD. BMR has been reported to increase by 57% in individuals with T2DM21,22. Oxygen species in the microvascular environment: Regulation of vascular tone and the development of hypertension. Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: All for one and one for all. Nutr. Check cost defrayal conditions with paying bodies. Bookshelf Image, Download Hi-res 85(1), 2634 (2007). The French (E) and Turkish (G) NAFLD external validation cohorts are well calibrated; their calibration curve is nearly linear, their intercept is close to zero (CIs include zero), and their slope is close to one (CIs include one). Unable to load your collection due to an error, Unable to load your delegates due to an error. PubMed Bethesda, MD 20894, Web Policies Scientific Reports %PDF-1.4 HHS Vulnerability Disclosure, Help Not all diseases are listed in the table. In summary, we believe the FAST score will allow for the more efficient identification of an at-risk group of patients with progressive NASH that merit consideration for further treatment. Association between uncoupling protein 2, adiponectin and resting energy expenditure in obese women with normal and low resting energy expenditure. Cite this article. Agarwal, R. Smoking, oxidative stress and inflammation: Impact on resting energy expenditure in diabetic nephropathy. Read across the row from left to right until you find the range that includes your fibrosis result. 100(3), 10781087 (2015). Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease. NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score Estimates amount of scarring in the liver based on several laboratory tests. 11 0 obj The authors declare no competing interests. Adiponectin, alanine transaminase, physical activity, diastolic blood pressure and fat free mass were independently associated with hypermetabolism in subjects with NAFLD and T2DM. Hepatol. FibroScan works similarly to an ultrasound, emitting a small pulse of energy, called a shear wave. The calibration plot characterises the agreement between observed proportion and predicted probabilities. According to the results of multivariable logistic regression analysis (Table 2), hypermetabolism was positively associated with adiponectin (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.021.34, p=0.030), physical activity (OR 1.13, 95% CI 1.0021.28, p=0.046), ALT (OR 1.06, 95% CI 1.0061.12, p=0.031) and diastolic blood pressure (OR 1.07, 95% CI 1.011.13, p=0.021). Tanase, D. M. et al. The formulas used were the HSI (hepatic steatosis index), FLI (fatty liver index), and the NAFLD fibrous score . Int. /Contents 12 0 R /F6 6 0 R J. Clin. Both LSM by VCTEand CAP are measured simultaneously without lengthening the examination time. After overnight fasting, intravenous blood was drawn to measure enzymes and biomarkers. /ExtGState << 76(1), 133137 (1994). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in fibroscan cap; fibroscan score; . Therap. The datasets used and/or analysed during the current study available from the corresponding author on reasonable request. Over 34% but less than 66% is moderate, while over 66% is severe. Your CAP score is a measurement of fatty change in your liver. PubMed Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV. livers can have up to 5% of fatty changes in them. CAP performance was not influenced by measurement variability, but was higher in patients with mild (F0-F1) fibrosis (AUROC 0.89 vs. 0.72 with F2-F4; P = 0.03). Utaka, S. et al. (Lausanne) 12, 768850 (2021). 2012 Jul;32(6):875-7. doi: 10.1111/j.1478-3231.2012.02824.x. To find a location near you with a FibroScan machine, use Echosens locator, which can be found here. Arrese, M. & Barrera, F. Concurrent nonalcoholic fatty liver disease and type 2 diabetes: Diagnostic and therapeutic considerations. 8 . In addition, among biochemical markers, subjects with non-hypermetabolism had a significantly higher level of low-density lipoprotein cholesterol (LDL-C), as compared with hypermetabolic cases (98.00 [68.00118.00] vs. 71.00 [61.00105.00], p=0.041). A total of 153 patients were included: 69% were male, median BMI was 32 kg/m(2); 47% had nonalcoholic fatty liver disease (NAFLD); and 65% had significant (10%) steatosis. Ther. 2011;141:12491253. Changes in eating habits and physical activity after COVID-19 pandemic lockdowns in Italy. After overnight fasting (at least 10h), oxygen consumption and carbon dioxide production were obtained for 20min with the participants lying down, without falling asleep, on a bed in a quiet environment. J. Behav. Copyright 2020 The Author(s). up to 5% of fatty changes in them. If you have more than one liver disease, you may not be able to use the table. The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial. /F7 7 0 R Ravussin, E. et al. /PCSp 4 0 R Hepatol. Background: Sci Rep 13, 3669 (2023). 2020 Apr;5(4):e3. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Metab. The current study suggested that adiponectin was a strong positive determinant for REE in individuals with NAFLD and T2DM. 3 0 obj While the present study found no association between inflammatory markers (CRP and TNF-) and hypermetabolism, the effect of inflammatory markers cannot be completely ruled out; this is because, in this study, we did not examine all inflammatory markers such as IL-6, etc. AUROC=area under the receiver operating curve. BMR is defined as the amount of energy the body consumes at complete rest in a thermally neutral environment after 1012h of fasting and a night sleep18. eCollection 2023 Jan. Taru MG, Neamti L, Taru V, Procopciuc LM, Procopet B, Lupsor-Platon M. Diagnostics (Basel). ET reports personal fees from Pfizer, Intercept, Gilead, Promethera, and Dr Falk, outside the submitted work. A score of less than 1.3 may be considered low-risk, while a Fib4 score of more than 3.25 could mean you're at a high risk for liver fibrosis. Snodgrass, J. J. et al. Article Article Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Clin. The prevalence of T2DM among NAFLD and non-alcoholic steatohepatitis (NASH) cases has been reported to be 22.5% and 43.6%, respectively6. Some studies have suggested that the diabetes per se, not the level of glucose level, is a major determinant of high REE in diabetic subjects37. According to the recent evidence, over fifty percent of individuals with T2DM concurrently have NAFLD8,9. These devices are designed for use in a medical practice in order to measure liver stiffness and ultrasound attenuation in patients with liver disease. CAS J. Nutr. If you have any questions or to schedule your Fibroscan, call our location nearest you or use our appointment request form. J. Diabetes Res. Emerg. NAFLD is substantially caused by visceral adipose tissue and insulin resistance10. Article Conclusions: Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Almost all drugs for NASH currently being assessed in clinical trials aim to treat the inflammatory activity associated with NASH, and therefore the population being considered for treatment are patients with active NASH (non-alcoholic fatty liver disease activity score 4) and significant fibrosis (stage F2). 286(4), F606F616 (2004). However, to do so we need to know which prevalence would be representative of the population, in whom the score would be used, and a robust reference cohort with that low prevalence. However, this cohort size is quite small (n=83). Funding: Article The mean age of the participants was 44.695.47years, and 67.40% of them were males. W-KC reports personal fees from Boehringer Ingelheim, Echosens, and Mylan; grants from Sysmex and Resonance Health; and non-financial support from Endosurgery, outside the submitted work. Patients with chronic liver disease and body mass index (BMI) 28 kg/m(2) underwent biopsy and liver stiffness measurement (LSM) with simultaneous CAP determination using the FibroScan() M probe. The FAST score provides an efficient way to non-invasively identify patients at risk of progressive NASH for clinical trials or treatments when they become available, and thereby reduce unnecessary liver biopsy in patients unlikely to have significant disease. Google Scholar. The accuracy (area under the curve: AU ROC) of liver steatosis (CAP) in patients with fatty liver with grades 5%, 34% and 67%, respectively, was 0, 92, 0.92 and 0.88.